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Assay Detail

CHEMBL3755853

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human aromatase extracted from placental microsomes using [1,2-3H]androstenedione as substrate after 30 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Yadav MR, Barmade MA, Tamboli RS, Murumkar PR.
Eur J Med Chem (2015) 105 : 1 -38
PubMed 26469743 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.39 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488 AMINOGLUTETHIMIDE 4.0 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488 AMINOGLUTETHIMIDE Ki = 4100.0 nM 5.39