Assay Detail
Binding
CHEMBL3755857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human aromatase extracted from placental microsomes using [1beta-3H]AD as substrate by radiometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.52 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753169 | — | — | 1 | 7.05 |
| CHEMBL3753403 | — | — | 1 | 6.60 |
| CHEMBL3753307 | — | — | 1 | 6.26 |
| CHEMBL3752414 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753169 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3753403 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3753307 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3752414 | — | IC50 | = | 690.0 | nM | 6.16 |