Assay Detail
Binding
CHEMBL3755860
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Inhibition of human aromatase extracted from placental microsomes using [1beta-3H]androstenedione as substrate after 20 mins by radiometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.07 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753611 | — | — | 1 | 6.85 |
| CHEMBL3754183 | — | — | 1 | 6.24 |
| CHEMBL3753352 | — | — | 1 | 6.15 |
| CHEMBL132530 | FORMESTANE | 2.0 | 1 | 5.92 |
| CHEMBL3754516 | — | — | 1 | 5.77 |
| CHEMBL3752351 | — | — | 1 | 5.77 |
| CHEMBL3752280 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753611 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3754183 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3753352 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL132530 | FORMESTANE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3754516 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3752351 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3752280 | — | IC50 | = | 1700.0 | nM | 5.77 |