Assay Detail
Binding
CHEMBL3755861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human aromatase extracted from placental microsomes by Dixon plot analysis in presence of [1beta-3H]androstenedione
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.84 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753810 | — | — | 1 | 8.33 |
| CHEMBL3752065 | — | — | 1 | 8.30 |
| CHEMBL3754719 | — | — | 1 | 8.09 |
| CHEMBL3752973 | — | — | 1 | 8.09 |
| CHEMBL3753667 | — | — | 1 | 8.09 |
| CHEMBL3752460 | — | — | 1 | 8.09 |
| CHEMBL3752149 | — | — | 1 | 6.84 |
| CHEMBL3752280 | — | — | 1 | 6.21 |
| CHEMBL3752699 | — | — | 1 | 5.96 |
| CHEMBL3753297 | — | — | 1 | 5.96 |
| CHEMBL3752351 | — | — | 1 | 5.26 |
| CHEMBL3753191 | — | — | 1 | 4.96 |
| CHEMBL3754516 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753810 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL3752065 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3754719 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3752973 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3753667 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3752460 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL3752149 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL3752280 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL3752699 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3753297 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3752351 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL3753191 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL3754516 | — | Ki | = | 16000.0 | nM | 4.80 |