Assay Detail
Binding
CHEMBL3756034
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Inhibition of recombinant human MMP2 after 2 hrs using FS-6 as substrate by fluorometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.51 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179288 | — | — | 1 | 9.10 |
| CHEMBL3754094 | — | — | 1 | 8.52 |
| CHEMBL1090284 | — | — | 1 | 7.54 |
| CHEMBL573714 | — | — | 1 | 6.64 |
| CHEMBL3754100 | — | — | 1 | 5.96 |
| CHEMBL3752513 | — | — | 1 | 5.70 |
| CHEMBL3753984 | — | — | 1 | 5.62 |
| CHEMBL3752374 | — | — | 1 | 5.05 |
| CHEMBL228230 | — | — | 1 | 4.47 |
| CHEMBL3751971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179288 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3754094 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1090284 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL573714 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3754100 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3752513 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3753984 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3752374 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL228230 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3751971 | — | IC50 | > | 10000.0 | nM | - |