Assay Detail
Binding
CHEMBL3756039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ADAM17 after 30 mins using FS-6 as substrate by fluorometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.80 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090284 | — | — | 1 | 5.96 |
| CHEMBL3752374 | — | — | 1 | 5.02 |
| CHEMBL179288 | — | — | 1 | 4.85 |
| CHEMBL573714 | — | — | 1 | 4.17 |
| CHEMBL228230 | — | — | 1 | 4.00 |
| CHEMBL3754094 | — | — | 1 | - |
| CHEMBL3753984 | — | — | 1 | - |
| CHEMBL3751971 | — | — | 1 | - |
| CHEMBL3754100 | — | — | 1 | - |
| CHEMBL3752513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090284 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3752374 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL179288 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL573714 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL228230 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3754094 | — | IC50 | - | — | - | |
| CHEMBL3753984 | — | IC50 | - | — | - | |
| CHEMBL3751971 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL3754100 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL3752513 | — | IC50 | - | — | - |