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Assay Detail

CHEMBL3756040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by SRB assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LoVo
Confidence 1 — Organism
Curated By Autocuration

Target

LoVo (CHEMBL614721)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
Grzywa R, Winiarski Ł, Psurski M, Rudnicka A, Wietrzyk J, Gajda T, Oleksyszyn J.
Bioorg Med Chem Lett (2016) 26 : 667 -671
PubMed 26639764 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.12 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.82
CHEMBL3752304 1 5.74
CHEMBL3752002 1 5.73
CHEMBL3752412 1 5.70
CHEMBL3752941 1 5.59
CHEMBL81201 1 5.43
CHEMBL3752507 1 5.43
CHEMBL3752573 1 5.38
CHEMBL3754532 1 5.33
CHEMBL3754699 1 5.28
CHEMBL3752524 1 5.15
CHEMBL2104676 BITOSCANATE 2.0 1 5.03
CHEMBL3753774 1 4.93
CHEMBL3754062 1 4.93
CHEMBL3752846 1 4.90
CHEMBL151649 PHENETHYLISOTHIOCYANATE 1 4.87
CHEMBL55285 BENZYL ISOTHIOCYANATE 1 4.84
CHEMBL3754172 1 4.69
CHEMBL3752558 1 4.63
CHEMBL3753220 1 4.45
CHEMBL3752230 1 4.44
CHEMBL3754345 1 4.33
CHEMBL1814589 1-ISOTHIOCYANATOPENTANE 1 4.05
CHEMBL3752979 1 -
CHEMBL3754758 1 -
CHEMBL2251726 PROPYL ISOTHIOCYANATE 1 -
CHEMBL1814588 BUTYL ISOTHIOCYANATE 1 -
CHEMBL3753982 1 -
CHEMBL3753294 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 150.0 nM 6.82
CHEMBL3752304 IC50 = 1840.0 nM 5.74
CHEMBL3752002 IC50 = 1880.0 nM 5.73
CHEMBL3752412 IC50 = 2020.0 nM 5.70
CHEMBL3752941 IC50 = 2590.0 nM 5.59
CHEMBL81201 IC50 = 3700.0 nM 5.43
CHEMBL3752507 IC50 = 3700.0 nM 5.43
CHEMBL3752573 IC50 = 4220.0 nM 5.38
CHEMBL3754532 IC50 = 4620.0 nM 5.33
CHEMBL3754699 IC50 = 5210.0 nM 5.28
CHEMBL3752524 IC50 = 7150.0 nM 5.15
CHEMBL2104676 BITOSCANATE IC50 = 9410.0 nM 5.03
CHEMBL3753774 IC50 = 11700.0 nM 4.93
CHEMBL3754062 IC50 = 11660.0 nM 4.93
CHEMBL3752846 IC50 = 12700.0 nM 4.90
CHEMBL151649 PHENETHYLISOTHIOCYANATE IC50 = 13500.0 nM 4.87
CHEMBL55285 BENZYL ISOTHIOCYANATE IC50 = 14500.0 nM 4.84
CHEMBL3754172 IC50 = 20490.0 nM 4.69
CHEMBL3752558 IC50 = 23470.0 nM 4.63
CHEMBL3753220 IC50 = 35220.0 nM 4.45
CHEMBL3752230 IC50 = 36600.0 nM 4.44
CHEMBL3754345 IC50 = 46370.0 nM 4.33
CHEMBL1814589 1-ISOTHIOCYANATOPENTANE IC50 = 88300.0 nM 4.05
CHEMBL3752979 IC50 - -
CHEMBL3754758 IC50 = 130000.0 nM -
CHEMBL2251726 PROPYL ISOTHIOCYANATE IC50 = 181000.0 nM -
CHEMBL1814588 BUTYL ISOTHIOCYANATE IC50 = 296000.0 nM -
CHEMBL3753982 IC50 = 150800.0 nM -
CHEMBL3753294 IC50 > 25000.0 nM -