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Assay Detail

CHEMBL3756043

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse BALB/3T3 cells after 72 hrs by SRB assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type BALB/3T3
Confidence 1 — Organism
Curated By Autocuration

Target

BALB/3T3 (CHEMBL613876)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
Grzywa R, Winiarski Ł, Psurski M, Rudnicka A, Wietrzyk J, Gajda T, Oleksyszyn J.
Bioorg Med Chem Lett (2016) 26 : 667 -671
PubMed 26639764 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.95 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.96
CHEMBL3752412 1 5.26
CHEMBL3754062 1 5.23
CHEMBL3754532 1 5.16
CHEMBL3752507 1 5.16
CHEMBL3752941 1 5.15
CHEMBL3754699 1 5.14
CHEMBL3752524 1 5.10
CHEMBL3752573 1 5.06
CHEMBL3753774 1 4.63
CHEMBL3752846 1 4.60
CHEMBL3752230 1 4.31
CHEMBL3754172 1 4.26
CHEMBL3752979 1 4.12
CHEMBL3752558 1 4.10
CHEMBL3753294 1 -
CHEMBL3753982 1 -
CHEMBL3754758 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 110.0 nM 6.96
CHEMBL3752412 IC50 = 5540.0 nM 5.26
CHEMBL3754062 IC50 = 5880.0 nM 5.23
CHEMBL3754532 IC50 = 6870.0 nM 5.16
CHEMBL3752507 IC50 = 6900.0 nM 5.16
CHEMBL3752941 IC50 = 7150.0 nM 5.15
CHEMBL3754699 IC50 = 7270.0 nM 5.14
CHEMBL3752524 IC50 = 7990.0 nM 5.10
CHEMBL3752573 IC50 = 8650.0 nM 5.06
CHEMBL3753774 IC50 = 23440.0 nM 4.63
CHEMBL3752846 IC50 = 25330.0 nM 4.60
CHEMBL3752230 IC50 = 48500.0 nM 4.31
CHEMBL3754172 IC50 = 54700.0 nM 4.26
CHEMBL3752979 IC50 = 75200.0 nM 4.12
CHEMBL3752558 IC50 = 79550.0 nM 4.10
CHEMBL3753294 IC50 > 100000.0 nM -
CHEMBL3753982 IC50 = 224000.0 nM -
CHEMBL3754758 IC50 = 206000.0 nM -