Assay Detail
Binding
CHEMBL3756170
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Inhibition of butter milk xanthine oxidase (unknown origin) assessed as initial velocity of uric acid formation pre-incubated for 3 mins by spectrophotometry analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.47 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | 4.0 | 1 | 8.51 |
| CHEMBL3752201 | — | — | 1 | 8.44 |
| CHEMBL3754370 | — | — | 1 | 8.29 |
| CHEMBL1078685 | TOPIROXOSTAT | 2.0 | 1 | 8.28 |
| CHEMBL3753402 | — | — | 1 | 8.24 |
| CHEMBL3751890 | — | — | 1 | 8.21 |
| CHEMBL3752928 | — | — | 1 | 8.16 |
| CHEMBL3753817 | — | — | 1 | 8.15 |
| CHEMBL3751912 | — | — | 1 | 8.05 |
| CHEMBL3752033 | — | — | 1 | 8.03 |
| CHEMBL3752385 | — | — | 1 | 8.03 |
| CHEMBL3752420 | — | — | 1 | 7.84 |
| CHEMBL3753938 | — | — | 1 | 7.80 |
| CHEMBL3753802 | — | — | 1 | 7.77 |
| CHEMBL3753979 | — | — | 1 | 7.50 |
| CHEMBL3752509 | — | — | 1 | 6.68 |
| CHEMBL3754087 | — | — | 1 | 6.63 |
| CHEMBL3754338 | — | — | 1 | 6.32 |
| CHEMBL3753355 | — | — | 1 | 6.28 |
| CHEMBL3753953 | — | — | 1 | 6.10 |
| CHEMBL3754326 | — | — | 1 | 5.66 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1164729 | FEBUXOSTAT | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3752201 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3754370 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1078685 | TOPIROXOSTAT | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3753402 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3751890 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3752928 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3753817 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3751912 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3752033 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL3752385 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3752420 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL3753938 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL3753802 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3753979 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL3752509 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL3754087 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3754338 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL3753355 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL3753953 | — | IC50 | = | 792.0 | nM | 6.10 |
| CHEMBL3754326 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 3740.0 | nM | 5.43 |