Assay Detail
Binding
CHEMBL3756249
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Inhibition of recombinant human IDO1 assessed as conversion of N-formylkynurenine to kynurenine incubated for 1 hr by fluorescence analysis
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.38 | 7.72 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753837 | — | — | 1 | 7.72 |
| CHEMBL3629569 | — | — | 1 | 7.42 |
| CHEMBL3754460 | — | — | 1 | 6.55 |
| CHEMBL3629570 | — | — | 1 | 6.33 |
| CHEMBL3753777 | — | — | 1 | 5.94 |
| CHEMBL3752209 | — | — | 1 | 4.32 |
| CHEMBL3752239 | — | — | 1 | - |
| CHEMBL3747548 | — | — | 1 | - |
| CHEMBL3754016 | — | — | 1 | - |
| CHEMBL3752732 | — | — | 1 | - |
| CHEMBL3752711 | — | — | 1 | - |
| CHEMBL3752060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753837 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3629569 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3754460 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL3629570 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL3753777 | — | IC50 | = | 1139.0 | nM | 5.94 |
| CHEMBL3752209 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3752239 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3747548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3754016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3752732 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3752711 | — | Inhibition | - | % | - | |
| CHEMBL3752060 | — | Inhibition | - | % | - |