Assay Detail
Binding
CHEMBL3756250
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Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells incubated for 24 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.69 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753837 | — | — | 1 | 7.26 |
| CHEMBL3629569 | — | — | 1 | 7.21 |
| CHEMBL3754460 | — | — | 1 | 6.14 |
| CHEMBL3629570 | — | — | 1 | 6.13 |
| CHEMBL3752239 | — | — | 1 | - |
| CHEMBL3747548 | — | — | 1 | - |
| CHEMBL3753777 | — | — | 1 | - |
| CHEMBL3752209 | — | — | 1 | - |
| CHEMBL3754016 | — | — | 1 | - |
| CHEMBL3752732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753837 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3629569 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3754460 | — | EC50 | = | 725.0 | nM | 6.14 |
| CHEMBL3629570 | — | EC50 | = | 749.0 | nM | 6.13 |
| CHEMBL3752239 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3747548 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3753777 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3752209 | — | EC50 | - | — | - | |
| CHEMBL3754016 | — | EC50 | - | — | - | |
| CHEMBL3752732 | — | EC50 | - | — | - |