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Assay Detail

CHEMBL3756423

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced NO production for 24 hrs by Griess reagent method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type N9
Confidence 1 — Organism
Curated By Autocuration

Target

N9 (CHEMBL613516)
Type CELL-LINE
Organism Homo sapiens

Publication

Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.
Handore KL, Jadhav PD, Hazra B, Basu A, Reddy DS.
ACS Med Chem Lett (2015) 6 : 1117 -1121
PubMed 26617964 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.87 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3752423 1 5.62
CHEMBL3753054 1 5.48
CHEMBL3753138 1 5.43
CHEMBL3752541 1 5.39
CHEMBL3753628 1 5.19
CHEMBL3753171 1 4.91
CHEMBL3752698 1 4.75
CHEMBL3752929 1 4.75
CHEMBL3751911 1 4.69
CHEMBL3754403 1 4.58
CHEMBL3751948 1 4.47
CHEMBL3754478 1 4.46
CHEMBL3751869 1 4.23
CHEMBL3753035 1 4.21
CHEMBL3754454 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3752423 IC50 = 2400.0 nM 5.62
CHEMBL3753054 IC50 = 3300.0 nM 5.48
CHEMBL3753138 IC50 = 3700.0 nM 5.43
CHEMBL3752541 IC50 = 4100.0 nM 5.39
CHEMBL3753628 IC50 = 6400.0 nM 5.19
CHEMBL3753171 IC50 = 12300.0 nM 4.91
CHEMBL3752698 IC50 = 18000.0 nM 4.75
CHEMBL3752929 IC50 = 17600.0 nM 4.75
CHEMBL3751911 IC50 = 20600.0 nM 4.69
CHEMBL3754403 IC50 = 26100.0 nM 4.58
CHEMBL3751948 IC50 = 34100.0 nM 4.47
CHEMBL3754478 IC50 = 34500.0 nM 4.46
CHEMBL3751869 IC50 = 58900.0 nM 4.23
CHEMBL3753035 IC50 = 61700.0 nM 4.21
CHEMBL3754454 IC50 = 177000.0 nM -