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Assay Detail

CHEMBL3756424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse N9 cells after 24 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type N9
Confidence 1 — Organism
Curated By Autocuration

Target

N9 (CHEMBL613516)
Type CELL-LINE
Organism Homo sapiens

Publication

Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.
Handore KL, Jadhav PD, Hazra B, Basu A, Reddy DS.
ACS Med Chem Lett (2015) 6 : 1117 -1121
PubMed 26617964 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.69 5.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3753138 1 5.28
CHEMBL3752423 1 5.09
CHEMBL3751869 1 4.21
CHEMBL3753628 1 4.17
CHEMBL3753054 1 -
CHEMBL3751911 1 -
CHEMBL3754478 1 -
CHEMBL3753035 1 -
CHEMBL3754454 1 -
CHEMBL3752698 1 -
CHEMBL3754403 1 -
CHEMBL3752541 1 -
CHEMBL3752929 1 -
CHEMBL3753171 1 -
CHEMBL3751948 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3753138 IC50 = 5300.0 nM 5.28
CHEMBL3752423 IC50 = 8100.0 nM 5.09
CHEMBL3751869 IC50 = 60900.0 nM 4.21
CHEMBL3753628 IC50 = 67300.0 nM 4.17
CHEMBL3753054 IC50 = 479500.0 nM -
CHEMBL3751911 IC50 = 132400.0 nM -
CHEMBL3754478 IC50 = 107200.0 nM -
CHEMBL3753035 IC50 = 678600.0 nM -
CHEMBL3754454 IC50 = 785800.0 nM -
CHEMBL3752698 IC50 = 299100.0 nM -
CHEMBL3754403 IC50 = 284200.0 nM -
CHEMBL3752541 IC50 = 570700.0 nM -
CHEMBL3752929 IC50 = 416200.0 nM -
CHEMBL3753171 IC50 = 183500.0 nM -
CHEMBL3751948 IC50 = 125800.0 nM -