Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3756503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Bacillus anthracis PurE by Surface Plasmon Resonance analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of B. anthracis N(5)-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening.
Lei H, Jones C, Zhu T, Patel K, Wolf NM, Fung LW, Lee H, Johnson ME.
Bioorg Med Chem (2016) 24 : 596 -605
PubMed 26740153 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 16 3.93 4.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3752329 1 4.87
CHEMBL3753771 1 4.69
CHEMBL3752946 1 4.45
CHEMBL3752172 1 4.22
CHEMBL3753446 1 4.14
CHEMBL3751853 1 4.10
CHEMBL1230231 1 3.99
CHEMBL3752417 1 3.92
CHEMBL3751985 1 3.83
CHEMBL3753511 1 3.80
CHEMBL23507 5-FLUOROINDOLE-2-CARBOXYLIC ACID 1 3.63
CHEMBL3752072 1 3.58
CHEMBL37537 PROTOCATECHUIC ACID 1 3.56
CHEMBL62083 1 3.52
CHEMBL3753055 1 3.35
CHEMBL3754476 1 3.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3752329 Kd = 13500.0 nM 4.87
CHEMBL3753771 Kd = 20300.0 nM 4.69
CHEMBL3752946 Kd = 35300.0 nM 4.45
CHEMBL3752172 Kd = 60800.0 nM 4.22
CHEMBL3753446 Kd = 73000.0 nM 4.14
CHEMBL3751853 Kd = 79800.0 nM 4.10
CHEMBL1230231 Kd = 103000.0 nM 3.99
CHEMBL3752417 Kd = 121000.0 nM 3.92
CHEMBL3751985 Kd = 149000.0 nM 3.83
CHEMBL3753511 Kd = 157000.0 nM 3.80
CHEMBL23507 5-FLUOROINDOLE-2-CARBOXYLIC ACID Kd = 234000.0 nM 3.63
CHEMBL3752072 Kd = 261000.0 nM 3.58
CHEMBL37537 PROTOCATECHUIC ACID Kd = 274000.0 nM 3.56
CHEMBL62083 Kd = 301000.0 nM 3.52
CHEMBL3753055 Kd = 444000.0 nM 3.35
CHEMBL3754476 Kd = 707000.0 nM 3.15