Assay Detail
Functional
CHEMBL3756526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1b
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.17 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 6.46 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.46 |
| CHEMBL1256180 | 5-(N-METHYL-N-ISOBUTYL)AMILORIDE | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1256180 | 5-(N-METHYL-N-ISOBUTYL)AMILORIDE | EC50 | = | 2500.0 | nM | 5.60 |