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Assay Detail

CHEMBL3756684

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human NMT1 by 7-diethylamine-3-(4'maleimidylphenyl)-4-methylcoumarin based fluorescence assay
25
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycylpeptide N-tetradecanoyltransferase 1 (CHEMBL2593)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.
Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW.
Medchemcomm (2015) 6 : 1767 -1772
PubMed 26962430 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.93 7.62
Ki(app) 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3754571 1 7.62
CHEMBL3753789 1 6.75
CHEMBL3752766 1 6.70
CHEMBL3754763 1 6.57
CHEMBL3753421 1 6.57
CHEMBL3753053 1 6.44
CHEMBL3753483 1 6.37
CHEMBL3754678 1 6.29
CHEMBL3754641 1 6.27
CHEMBL3754615 1 6.14
CHEMBL3753269 1 6.00
CHEMBL3754427 1 5.92
CHEMBL3754110 1 5.85
CHEMBL3754347 1 5.77
CHEMBL3754003 1 5.64
CHEMBL3753135 1 5.31
CHEMBL3752013 1 4.82
CHEMBL3753299 1 4.77
CHEMBL3754584 1 4.47
CHEMBL3751916 1 4.36
CHEMBL3754410 1 -
CHEMBL3754499 1 -
CHEMBL3754529 1 -
CHEMBL3752787 1 -
CHEMBL3753336 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3754571 Ki = 24.0 nM 7.62
CHEMBL3753789 Ki = 180.0 nM 6.75
CHEMBL3752766 Ki = 200.0 nM 6.70
CHEMBL3754763 Ki = 270.0 nM 6.57
CHEMBL3753421 Ki = 270.0 nM 6.57
CHEMBL3753053 Ki = 360.0 nM 6.44
CHEMBL3753483 Ki = 430.0 nM 6.37
CHEMBL3754678 Ki = 510.0 nM 6.29
CHEMBL3754641 Ki = 540.0 nM 6.27
CHEMBL3754615 Ki = 730.0 nM 6.14
CHEMBL3753269 Ki = 1000.0 nM 6.00
CHEMBL3754427 Ki = 1200.0 nM 5.92
CHEMBL3754110 Ki = 1400.0 nM 5.85
CHEMBL3754347 Ki = 1700.0 nM 5.77
CHEMBL3754003 Ki = 2300.0 nM 5.64
CHEMBL3753135 Ki = 4900.0 nM 5.31
CHEMBL3752013 Ki = 15000.0 nM 4.82
CHEMBL3753299 Ki = 17000.0 nM 4.77
CHEMBL3754584 Ki = 34000.0 nM 4.47
CHEMBL3751916 Ki = 44000.0 nM 4.36
CHEMBL3754410 Ki(app) - -
CHEMBL3754499 Ki(app) - -
CHEMBL3754529 Ki(app) - -
CHEMBL3752787 Ki(app) - -
CHEMBL3753336 Ki(app) - -