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Assay Detail

CHEMBL3756711

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to HCV NS4B protease by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.
Cannalire R, Barreca ML, Manfroni G, Cecchetti V.
J Med Chem (2016) 59 : 16 -41
PubMed 26241789 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 8 5.97 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL210149 1 6.52
CHEMBL3753995 1 6.52
CHEMBL2170006 ANGUIZOLE 1 6.18
CHEMBL3752261 1 6.00
CHEMBL1539307 1 5.92
CHEMBL511979 1 5.77
CHEMBL3754395 1 5.68
CHEMBL3752686 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL210149 Kd = 300.0 nM 6.52
CHEMBL3753995 Kd = 300.0 nM 6.52
CHEMBL2170006 ANGUIZOLE Kd = 662.0 nM 6.18
CHEMBL3752261 Kd = 1000.0 nM 6.00
CHEMBL1539307 Kd = 1200.0 nM 5.92
CHEMBL511979 Kd = 1700.0 nM 5.77
CHEMBL3754395 Kd = 2100.0 nM 5.68
CHEMBL3752686 Kd = 6900.0 nM 5.16