Assay Detail
Functional
CHEMBL3756745
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Antiviral activity against HCV genotype 1b infected in human Huh7 cells assessed as inhibition of viral replication after 72 hrs by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.81 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753995 | — | — | 1 | 6.16 |
| CHEMBL210149 | — | — | 1 | 6.06 |
| CHEMBL1539307 | — | — | 1 | 5.95 |
| CHEMBL511979 | — | — | 1 | 5.82 |
| CHEMBL3754395 | — | — | 1 | 5.66 |
| CHEMBL3752686 | — | — | 1 | 5.55 |
| CHEMBL3752261 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753995 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL210149 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1539307 | — | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL511979 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3754395 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3752686 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3752261 | — | EC50 | = | 3200.0 | nM | 5.50 |