Assay Detail

CHEMBL3756746

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV genotype 2a

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

A Journey around the Medicinal Chemistry of Hepatitis C Virus Inhibitors Targeting NS4B: From Target to Preclinical Drug Candidates.

Cannalire R, Barreca ML, Manfroni G, Cecchetti V.
J Med Chem (2016) 59 : 16 -41
PubMed 26241789 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.43	5.43

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1256180	5-(N-METHYL-N-ISOBUTYL)AMILORIDE	—	1	5.43

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1256180	5-(N-METHYL-N-ISOBUTYL)AMILORIDE	EC50	=	3700.0	nM	5.43