Assay Detail
Binding
CHEMBL3756951
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Inhibition of human aromatase extracted from placental microsomes using [1beta-3H]androstenedione as substrate after 15 mins by scintillation counting analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 6.33 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623223 | — | — | 1 | 6.33 |
| CHEMBL3623224 | — | — | 1 | - |
| CHEMBL3753311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623223 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3623224 | — | Inhibition | = | 93.8 | % | - |
| CHEMBL3753311 | — | Inhibition | = | 32.8 | % | - |