Assay Detail
Binding
CHEMBL3757541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of S-adenosylhomocysteine hydrolase (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
S-adenosylhomocysteine hydrolase-like protein 1 (CHEMBL3751646) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Enantiomeric 3-deaza-1',6'-isoneplanocin and its 3-bromo analogue: Synthesis by the Ullmann reaction and their antiviral properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.49 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2059155 | — | — | 1 | 8.57 |
| CHEMBL3753637 | — | — | 1 | 8.49 |
| CHEMBL3753746 | — | — | 1 | 7.89 |
| CHEMBL3754027 | — | — | 1 | 5.00 |
| CHEMBL3753489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2059155 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3753637 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3753746 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3754027 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3753489 | — | IC50 | > | 10000.0 | nM | - |