Assay Detail
Binding
CHEMBL3757557
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Inhibition of ASCT2 (unknown origin)-mediated glutamine transport
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neutral amino acid transporter B(0) (CHEMBL3562162) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.98 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753379 | — | — | 1 | 5.43 |
| CHEMBL3576945 | — | — | 1 | 4.52 |
| CHEMBL3576929 | — | — | 1 | - |
| CHEMBL6251 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753379 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3576945 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3576929 | — | IC50 | = | 312000.0 | nM | - |
| CHEMBL6251 | — | IC50 | = | 1000000.0 | nM | - |