Assay Detail
Binding
CHEMBL3757723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from recombinant human GluN1a/GluN2B expressed in L(tk-)cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.09 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 8.00 |
| CHEMBL1289626 | — | — | 1 | 7.85 |
| CHEMBL3753409 | — | — | 1 | 7.14 |
| CHEMBL3752293 | — | — | 1 | 6.39 |
| CHEMBL3752701 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1289626 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3753409 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL3752293 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL3752701 | — | Ki | = | 887.0 | nM | 6.05 |