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Assay Detail

CHEMBL3757725

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to sigma-2 receptor (unknown origin) by radioligand displacement assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold.
Dey S, Schepmann D, Wünsch B.
Bioorg Med Chem Lett (2016) 26 : 889 -893
PubMed 26750254 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 6.77 7.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL282433 DITOLYLGUANIDINE 1 7.24
CHEMBL3753409 1 7.12
CHEMBL54 HALOPERIDOL 4.0 1 7.11
CHEMBL319706 (S)-IFENPRODIL 1 7.01
CHEMBL3752293 1 6.22
CHEMBL3752701 1 5.89
CHEMBL1289626 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL282433 DITOLYLGUANIDINE Ki = 58.0 nM 7.24
CHEMBL3753409 Ki = 76.0 nM 7.12
CHEMBL54 HALOPERIDOL Ki = 78.0 nM 7.11
CHEMBL319706 (S)-IFENPRODIL Ki = 98.0 nM 7.01
CHEMBL3752293 Ki = 598.0 nM 6.22
CHEMBL3752701 Ki = 1300.0 nM 5.89
CHEMBL1289626 Ki > 10000.0 nM -