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Assay Detail

CHEMBL3757741

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against mefloquine-resistant Plasmodium falciparum D6 assessed as inhibition of [3H]-hypoxanthine uptake after 48 hrs by liquid scintillation counting analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.
Gutteridge CE, Major JW, Nin DA, Curtis SM, Bhattacharjee AK, Gerena L, Nichols DA.
Bioorg Med Chem Lett (2016) 26 : 1048 -1051
PubMed 26750257 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.05 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 6.62
CHEMBL226715 4',4-DICHLOROCHALCONE 1 5.58
CHEMBL3754215 1 5.50
CHEMBL3751855 1 5.35
CHEMBL3754684 1 5.17
CHEMBL3754405 1 5.16
CHEMBL3753756 1 5.14
CHEMBL3754342 1 5.11
CHEMBL3753913 1 5.01
CHEMBL3754225 1 4.96
CHEMBL3752970 1 4.92
CHEMBL3752615 1 4.89
CHEMBL3752445 1 4.85
CHEMBL3754179 1 4.85
CHEMBL3753684 1 4.85
CHEMBL3752486 1 4.85
CHEMBL3752731 1 4.82
CHEMBL3753794 1 4.82
CHEMBL3752177 1 4.82
CHEMBL3753506 1 4.75
CHEMBL3754382 1 4.72
CHEMBL3753627 1 4.72
CHEMBL3753116 1 4.70
CHEMBL3754367 1 -
CHEMBL3753296 1 -
CHEMBL3751962 1 -
CHEMBL3754361 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 240.0 nM 6.62
CHEMBL226715 4',4-DICHLOROCHALCONE IC50 = 2600.0 nM 5.58
CHEMBL3754215 IC50 = 3200.0 nM 5.50
CHEMBL3751855 IC50 = 4500.0 nM 5.35
CHEMBL3754684 IC50 = 6700.0 nM 5.17
CHEMBL3754405 IC50 = 6900.0 nM 5.16
CHEMBL3753756 IC50 = 7300.0 nM 5.14
CHEMBL3754342 IC50 = 7700.0 nM 5.11
CHEMBL3753913 IC50 = 9800.0 nM 5.01
CHEMBL3754225 IC50 = 11000.0 nM 4.96
CHEMBL3752970 IC50 = 12000.0 nM 4.92
CHEMBL3752615 IC50 = 13000.0 nM 4.89
CHEMBL3752445 IC50 = 14000.0 nM 4.85
CHEMBL3754179 IC50 = 14000.0 nM 4.85
CHEMBL3753684 IC50 = 14000.0 nM 4.85
CHEMBL3752486 IC50 = 14000.0 nM 4.85
CHEMBL3752731 IC50 = 15000.0 nM 4.82
CHEMBL3753794 IC50 = 15000.0 nM 4.82
CHEMBL3752177 IC50 = 15000.0 nM 4.82
CHEMBL3753506 IC50 = 18000.0 nM 4.75
CHEMBL3754382 IC50 = 19000.0 nM 4.72
CHEMBL3753627 IC50 = 19000.0 nM 4.72
CHEMBL3753116 IC50 = 20000.0 nM 4.70
CHEMBL3754367 IC50 > 27000.0 nM -
CHEMBL3753296 IC50 > 27000.0 nM -
CHEMBL3751962 IC50 > 27000.0 nM -
CHEMBL3754361 IC50 > 17000.0 nM -