Assay Detail
Binding
CHEMBL3757817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 125I-labelled Sar1-Ile8-angiotensin-2 from human AT1 receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-[(benzimidazol-1-yl) methyl]biphenyl-2-amides as dual angiotensin II and endothelin A receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.10 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752680 | — | — | 1 | 8.41 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.79 |
| CHEMBL3753458 | — | — | 1 | 7.58 |
| CHEMBL3752160 | — | — | 1 | 7.51 |
| CHEMBL3751994 | — | — | 1 | 7.48 |
| CHEMBL3752530 | — | — | 1 | 7.43 |
| CHEMBL3752947 | — | — | 1 | 7.36 |
| CHEMBL3751986 | — | — | 1 | 7.27 |
| CHEMBL3753134 | — | — | 1 | 7.27 |
| CHEMBL3754267 | — | — | 1 | 7.17 |
| CHEMBL3753888 | — | — | 1 | 7.16 |
| CHEMBL3752444 | — | — | 1 | 7.13 |
| CHEMBL3752117 | — | — | 1 | 7.13 |
| CHEMBL3753406 | — | — | 1 | 7.09 |
| CHEMBL3752145 | — | — | 1 | 7.06 |
| CHEMBL3753277 | — | — | 1 | 7.05 |
| CHEMBL3754394 | — | — | 1 | 7.03 |
| CHEMBL3753047 | — | — | 1 | 6.85 |
| CHEMBL3752198 | — | — | 1 | 6.79 |
| CHEMBL3751899 | — | — | 1 | 6.46 |
| CHEMBL3754661 | — | — | 1 | 6.44 |
| CHEMBL3754198 | — | — | 1 | 6.41 |
| CHEMBL3754010 | — | — | 1 | 6.36 |
| CHEMBL3753007 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752680 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL191 | LOSARTAN | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL3753458 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL3752160 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL3751994 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL3752530 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL3752947 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3751986 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL3753134 | — | IC50 | = | 53.9 | nM | 7.27 |
| CHEMBL3754267 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL3753888 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL3752444 | — | IC50 | = | 73.7 | nM | 7.13 |
| CHEMBL3752117 | — | IC50 | = | 73.3 | nM | 7.13 |
| CHEMBL3753406 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3752145 | — | IC50 | = | 87.8 | nM | 7.06 |
| CHEMBL3753277 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3754394 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3753047 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3752198 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3751899 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL3754661 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL3754198 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3754010 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL3753007 | — | IC50 | = | 549.8 | nM | 6.26 |