Assay Detail
Binding
CHEMBL3757886
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Displacement of [3H]N-methylspiperone from human cloned D2 dopamine receptor expressed in human fibroblasts incubated for 90 mins by scintillation counting based radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
D1-like receptors distinguishing thieno-azecine regioisomers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.23 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187365 | ASENAPINE | 4.0 | 1 | 8.05 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.28 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187365 | ASENAPINE | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL715 | OLANZAPINE | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL42 | CLOZAPINE | Ki | = | 431.0 | nM | 6.37 |