Assay Detail
Binding
CHEMBL3760464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Vibrio cholerae beta-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vibrio cholerae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 5.90 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265674 | — | — | 1 | 7.17 |
| CHEMBL6753 | — | — | 1 | 7.08 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 7.06 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.56 |
| CHEMBL6919 | — | — | 1 | 6.52 |
| CHEMBL224292 | — | — | 1 | 6.46 |
| CHEMBL7146 | — | — | 1 | 6.44 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.35 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.34 |
| CHEMBL6852 | — | — | 1 | 6.33 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.29 |
| CHEMBL269122 | — | — | 1 | 6.12 |
| CHEMBL2324868 | — | — | 1 | 6.11 |
| CHEMBL266026 | — | — | 1 | 6.09 |
| CHEMBL268439 | — | — | 1 | 6.07 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.07 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.07 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.06 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.06 |
| CHEMBL6633 | — | — | 1 | 5.65 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.63 |
| CHEMBL6784 | — | — | 1 | 5.45 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.38 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 5.35 |
| CHEMBL2324864 | — | — | 1 | 5.35 |
| CHEMBL266240 | — | — | 1 | 5.35 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 5.33 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 5.20 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 5.20 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265674 | — | Ki | = | 68.1 | nM | 7.17 |
| CHEMBL6753 | — | Ki | = | 82.3 | nM | 7.08 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL310671 | SACCHARIN | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL6919 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL224292 | — | Ki | = | 349.0 | nM | 6.46 |
| CHEMBL7146 | — | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL328560 | SULTHIAME | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL6852 | — | Ki | = | 463.0 | nM | 6.33 |
| CHEMBL414 | CARZENIDE | Ki | = | 515.0 | nM | 6.29 |
| CHEMBL269122 | — | Ki | = | 757.0 | nM | 6.12 |
| CHEMBL2324868 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL266026 | — | Ki | = | 817.0 | nM | 6.09 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 846.0 | nM | 6.07 |
| CHEMBL268439 | — | Ki | = | 859.0 | nM | 6.07 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 845.0 | nM | 6.07 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 879.0 | nM | 6.06 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 874.0 | nM | 6.06 |
| CHEMBL6633 | — | Ki | = | 2218.0 | nM | 5.65 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 2352.0 | nM | 5.63 |
| CHEMBL6784 | — | Ki | = | 3530.0 | nM | 5.45 |
| CHEMBL118 | CELECOXIB | Ki | = | 4165.0 | nM | 5.38 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 4512.0 | nM | 5.35 |
| CHEMBL2324864 | — | Ki | = | 4430.0 | nM | 5.35 |
| CHEMBL266240 | — | Ki | = | 4450.0 | nM | 5.35 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 4728.0 | nM | 5.33 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 6260.0 | nM | 5.20 |
| CHEMBL26 | SULPIRIDE | Ki | = | 6245.0 | nM | 5.20 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 6450.0 | nM | 5.19 |
| CHEMBL77517 | INDISULAM | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL865 | VALDECOXIB | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 8570.0 | nM | 5.07 |
| CHEMBL7092 | — | Ki | = | 9120.0 | nM | 5.04 |
| CHEMBL6724 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | > | 10000.0 | nM | - |
| CHEMBL419 | MAFENIDE | Ki | > | 10000.0 | nM | - |
| CHEMBL7087 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL6853 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2324869 | — | Ki | > | 10000.0 | nM | - |