Assay Detail
Functional
CHEMBL3760799
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.83 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 10.00 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.30 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.60 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.44 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.37 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.64 |
| CHEMBL3759534 | — | — | 1 | 5.43 |
| CHEMBL241806 | TEPHROSIN | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL3759534 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL241806 | TEPHROSIN | IC50 | = | 13270.0 | nM | 4.88 |