Assay Detail
Functional
CHEMBL3760800
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.44 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 9.84 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.35 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 8.12 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.34 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.34 |
| CHEMBL3759534 | — | — | 1 | 5.16 |
| CHEMBL241806 | TEPHROSIN | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 0.146 | nM | 9.84 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.443 | nM | 9.35 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 7.51 | nM | 8.12 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 45.5 | nM | 7.34 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 45.2 | nM | 7.34 |
| CHEMBL3759534 | — | IC50 | = | 6970.0 | nM | 5.16 |
| CHEMBL241806 | TEPHROSIN | IC50 | = | 12050.0 | nM | 4.92 |