Assay Detail
Binding
CHEMBL3761048
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Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.47 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.85 |
| CHEMBL3759529 | — | — | 1 | 4.08 |
| CHEMBL3759749 | — | — | 1 | - |
| CHEMBL3759699 | — | — | 1 | - |
| CHEMBL3758656 | — | — | 1 | - |
| CHEMBL3758253 | — | — | 1 | - |
| CHEMBL3758791 | — | — | 1 | - |
| CHEMBL3758432 | — | — | 1 | - |
| CHEMBL3758528 | — | — | 1 | - |
| CHEMBL1087807 | — | — | 1 | - |
| CHEMBL1087690 | — | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL3759529 | — | IC50 | = | 84200.0 | nM | 4.08 |
| CHEMBL3759749 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL3759699 | — | IC50 | = | 786000.0 | nM | - |
| CHEMBL3758656 | — | IC50 | = | 217000.0 | nM | - |
| CHEMBL3758253 | — | IC50 | = | 188000.0 | nM | - |
| CHEMBL3758791 | — | IC50 | = | 495000.0 | nM | - |
| CHEMBL3758432 | — | IC50 | - | — | - | |
| CHEMBL3758528 | — | IC50 | - | — | - | |
| CHEMBL1087807 | — | IC50 | = | 347000.0 | nM | - |
| CHEMBL1087690 | — | IC50 | = | 5620000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | = | 187000.0 | nM | - |