Assay Detail
Functional
CHEMBL3761233
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Cytotoxic activity against human NCI-H460 cells assessed as inhibition of cell growth after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.62 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3758801 | — | — | 1 | 5.09 |
| CHEMBL3759818 | — | — | 1 | 4.89 |
| CHEMBL3759248 | — | — | 1 | 4.86 |
| CHEMBL3760052 | — | — | 1 | 4.86 |
| CHEMBL3759783 | — | — | 1 | 4.85 |
| CHEMBL3759598 | — | — | 1 | 4.62 |
| CHEMBL3759902 | — | — | 1 | 4.55 |
| CHEMBL3759729 | — | — | 1 | 4.49 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.45 |
| CHEMBL3759966 | — | — | 1 | 4.42 |
| CHEMBL3759664 | — | — | 1 | 4.42 |
| CHEMBL3758708 | — | — | 1 | 4.39 |
| CHEMBL12850 | DEHYDROABIETIC ACID | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3758801 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3759818 | — | IC50 | = | 12970.0 | nM | 4.89 |
| CHEMBL3759248 | — | IC50 | = | 13930.0 | nM | 4.86 |
| CHEMBL3760052 | — | IC50 | = | 13740.0 | nM | 4.86 |
| CHEMBL3759783 | — | IC50 | = | 14170.0 | nM | 4.85 |
| CHEMBL3759598 | — | IC50 | = | 24040.0 | nM | 4.62 |
| CHEMBL3759902 | — | IC50 | = | 28270.0 | nM | 4.55 |
| CHEMBL3759729 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 35520.0 | nM | 4.45 |
| CHEMBL3759966 | — | IC50 | = | 38210.0 | nM | 4.42 |
| CHEMBL3759664 | — | IC50 | = | 37650.0 | nM | 4.42 |
| CHEMBL3758708 | — | IC50 | = | 40890.0 | nM | 4.39 |
| CHEMBL12850 | DEHYDROABIETIC ACID | IC50 | = | 75050.0 | nM | 4.12 |