Assay Detail
Binding
CHEMBL3761384
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Inhibition of voltage-gated calcium channel in Wistar rat synaptoneurosomes after 30 mins by fluorescent ratiometric indicator method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.56 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 8.10 |
| CHEMBL1830325 | — | — | 1 | 6.57 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.48 |
| CHEMBL3758459 | — | — | 1 | 6.32 |
| CHEMBL3759841 | — | — | 1 | 6.01 |
| CHEMBL1189234 | — | — | 1 | 4.46 |
| CHEMBL391409 | — | — | 1 | 4.07 |
| CHEMBL3758822 | — | — | 1 | 4.00 |
| CHEMBL1830320 | — | — | 1 | 4.00 |
| CHEMBL50588 | EMETINE | 4.0 | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1428 | NIMODIPINE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1830325 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3758459 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3759841 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL1189234 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL391409 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3758822 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1830320 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL50588 | EMETINE | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - |