Assay Detail
Functional
CHEMBL3761482
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Antimalarial activity against chloroquine-sensitive NF54 isolated Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of parasitic growth after 48 hrs by optical microscopy
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.34 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 6.75 |
| CHEMBL2059460 | — | — | 1 | 5.43 |
| CHEMBL3758643 | — | — | 1 | 5.40 |
| CHEMBL415711 | — | — | 1 | 5.29 |
| CHEMBL2059372 | — | — | 1 | 5.29 |
| CHEMBL2059459 | — | — | 1 | 5.21 |
| CHEMBL84010 | — | — | 1 | 5.20 |
| CHEMBL318782 | Dichlon | — | 1 | 4.86 |
| CHEMBL192627 | CHLORANIL | — | 1 | 4.65 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | — | 1 | - |
| CHEMBL3759616 | — | — | 1 | - |
| CHEMBL518583 | — | — | 1 | - |
| CHEMBL508314 | — | — | 1 | - |
| CHEMBL2059371 | — | — | 1 | - |
| CHEMBL2059458 | — | — | 1 | - |
| CHEMBL3759217 | — | — | 1 | - |
| CHEMBL3759302 | — | — | 1 | - |
| CHEMBL3759231 | — | — | 1 | - |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2059460 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL3758643 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL415711 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL2059372 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL2059459 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL84010 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL318782 | Dichlon | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL192627 | CHLORANIL | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | IC50 | > | 50000.0 | nM | - |
| CHEMBL3759616 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL518583 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL508314 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2059371 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2059458 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3759217 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3759302 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3759231 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | > | 50000.0 | nM | - |