Assay Detail
Binding
CHEMBL3761673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.62 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342693 | — | — | 1 | 9.05 |
| CHEMBL412099 | — | — | 1 | 8.28 |
| CHEMBL3758222 | — | — | 1 | 7.99 |
| CHEMBL3758663 | — | — | 1 | 7.71 |
| CHEMBL3758879 | — | — | 1 | 7.13 |
| CHEMBL2152710 | — | — | 1 | 6.70 |
| CHEMBL2152712 | LY-3031207 | 1.0 | 1 | 6.62 |
| CHEMBL3758186 | — | — | 1 | 6.42 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.37 |
| CHEMBL3758743 | — | — | 1 | 6.17 |
| CHEMBL2152711 | — | — | 1 | 6.05 |
| CHEMBL3759737 | — | — | 1 | 5.97 |
| CHEMBL3760032 | — | — | 1 | 5.95 |
| CHEMBL3759119 | — | — | 1 | 5.63 |
| CHEMBL3760103 | — | — | 1 | 5.61 |
| CHEMBL3759709 | — | — | 1 | 5.51 |
| CHEMBL3758980 | — | — | 1 | 5.43 |
| CHEMBL3759288 | — | — | 1 | - |
| CHEMBL3758924 | — | — | 1 | - |
| CHEMBL3758953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342693 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL412099 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3758222 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL3758663 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL3758879 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2152710 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL2152712 | LY-3031207 | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL3758186 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL118 | CELECOXIB | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL3758743 | — | IC50 | = | 676.0 | nM | 6.17 |
| CHEMBL2152711 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL3759737 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL3760032 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3759119 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL3760103 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL3759709 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL3758980 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3759288 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL3758924 | — | IC50 | < | 3.0 | nM | - |
| CHEMBL3758953 | — | IC50 | < | 3.0 | nM | - |