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Assay Detail

CHEMBL3761956

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania major promastigotes after 72 hrs by Neubauer counting chamber based microscopy
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania major
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania major (CHEMBL612879)
Type ORGANISM
Organism Leishmania major

Publication

4-Arylamino-6-nitroquinazolines: Synthesis and their activities against neglected disease leishmaniasis.
Saad SM, Ghouri N, Perveen S, Khan KM, Choudhary MI.
Eur J Med Chem (2016) 108 : 13 -20
PubMed 26619389 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.86 5.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3758748 1 5.73
CHEMBL3758369 1 5.36
CHEMBL55 PENTAMIDINE 4.0 1 5.29
CHEMBL3758623 1 5.18
CHEMBL329161 1 5.04
CHEMBL3758611 1 4.91
CHEMBL3760067 1 4.70
CHEMBL3759143 1 4.62
CHEMBL3758240 1 4.45
CHEMBL3759644 1 4.42
CHEMBL3758550 1 4.35
CHEMBL3760107 1 4.21
CHEMBL3758295 1 -
CHEMBL3759269 1 -
CHEMBL3758660 1 -
CHEMBL3759770 1 -
CHEMBL3758690 1 -
CHEMBL3758227 1 -
CHEMBL1080816 1 -
CHEMBL3760036 1 -
CHEMBL3759943 1 -
CHEMBL328295 1 -
CHEMBL3759777 1 -
CHEMBL3759194 1 -
CHEMBL3759047 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3758748 IC50 = 1870.0 nM 5.73
CHEMBL3758369 IC50 = 4370.0 nM 5.36
CHEMBL55 PENTAMIDINE IC50 = 5090.0 nM 5.29
CHEMBL3758623 IC50 = 6530.0 nM 5.18
CHEMBL329161 IC50 = 9040.0 nM 5.04
CHEMBL3758611 IC50 = 12280.0 nM 4.91
CHEMBL3760067 IC50 = 19870.0 nM 4.70
CHEMBL3759143 IC50 = 24030.0 nM 4.62
CHEMBL3758240 IC50 = 35880.0 nM 4.45
CHEMBL3759644 IC50 = 38170.0 nM 4.42
CHEMBL3758550 IC50 = 44910.0 nM 4.35
CHEMBL3760107 IC50 = 61480.0 nM 4.21
CHEMBL3758295 IC50 - -
CHEMBL3759269 IC50 - -
CHEMBL3758660 IC50 - -
CHEMBL3759770 IC50 - -
CHEMBL3758690 IC50 - -
CHEMBL3758227 IC50 - -
CHEMBL1080816 IC50 - -
CHEMBL3760036 IC50 - -
CHEMBL3759943 IC50 - -
CHEMBL328295 IC50 - -
CHEMBL3759777 IC50 - -
CHEMBL3759194 IC50 - -
CHEMBL3759047 IC50 - -