Assay Detail
Binding
CHEMBL3762073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Raclopride from human D2L receptor expressed in HEK293 cells after 1 hr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.89 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3759205 | — | — | 1 | 7.22 |
| CHEMBL3759819 | — | — | 1 | 7.03 |
| CHEMBL3740054 | — | — | 1 | 6.99 |
| CHEMBL3759617 | — | — | 1 | 6.70 |
| CHEMBL3758591 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3759205 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3759819 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL3740054 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL3759617 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL3758591 | — | Ki | = | 322.0 | nM | 6.49 |