Assay Detail
Binding
CHEMBL3762498
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Inhibition of recombinant GST-fused SUMO E1 (unknown origin) using RanGAP1 as substrate after 2 hrs by immunoblot analysis
9
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.48 | 4.87 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471230 | — | — | 1 | 4.87 |
| CHEMBL3759613 | — | — | 1 | 4.86 |
| CHEMBL3758249 | — | — | 1 | 4.52 |
| CHEMBL3758566 | — | — | 2 | 4.48 |
| CHEMBL3758383 | — | — | 1 | 4.14 |
| CHEMBL3758250 | — | — | 2 | 4.03 |
| CHEMBL3759177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471230 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL3759613 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3758249 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL3758566 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL3758383 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL3758250 | — | IC50 | = | 92600.0 | nM | 4.03 |
| CHEMBL3758250 | — | Inhibition | - | % | - | |
| CHEMBL3758566 | — | Inhibition | - | % | - | |
| CHEMBL3759177 | — | IC50 | > | 100000.0 | nM | - |