Assay Detail
Binding
CHEMBL3762503
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Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.81 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3758979 | — | — | 1 | 7.75 |
| CHEMBL3759629 | — | — | 1 | 7.72 |
| CHEMBL3759331 | — | — | 1 | 7.72 |
| CHEMBL3758923 | — | — | 1 | 7.66 |
| CHEMBL1391313 | — | — | 1 | 7.64 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL3758428 | — | — | 1 | 7.58 |
| CHEMBL3759876 | — | — | 1 | 7.57 |
| CHEMBL3760060 | — | — | 1 | 7.29 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.99 |
| CHEMBL3760047 | — | — | 1 | 6.79 |
| CHEMBL79350 | — | — | 1 | 6.76 |
| CHEMBL3758327 | — | — | 1 | 6.74 |
| CHEMBL1472681 | — | — | 1 | 6.72 |
| CHEMBL3759518 | — | — | 1 | 6.71 |
| CHEMBL3758420 | — | — | 1 | 6.68 |
| CHEMBL1489759 | — | — | 1 | 6.66 |
| CHEMBL2429920 | — | — | 1 | 6.65 |
| CHEMBL3759375 | — | — | 1 | 6.63 |
| CHEMBL3758373 | — | — | 1 | 6.62 |
| CHEMBL3760113 | — | — | 1 | 6.58 |
| CHEMBL3759099 | — | — | 1 | 6.58 |
| CHEMBL3125555 | — | — | 1 | 6.51 |
| CHEMBL3759608 | — | — | 1 | 6.27 |
| CHEMBL3759443 | — | — | 1 | 6.21 |
| CHEMBL3759882 | — | — | 1 | 5.93 |
| CHEMBL3759447 | — | — | 1 | 5.80 |
| CHEMBL1351474 | ACESULFAME POTASSIUM | 3.0 | 1 | 5.62 |
| CHEMBL3759567 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3758979 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3759629 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3759331 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3758923 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL1391313 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3758428 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3759876 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3760060 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL310671 | SACCHARIN | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3760047 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL79350 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL3758327 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL1472681 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL3759518 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL3758420 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1489759 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL2429920 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL3759375 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL3758373 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL3760113 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL3759099 | — | Ki | = | 261.0 | nM | 6.58 |
| CHEMBL3125555 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3759608 | — | Ki | = | 539.0 | nM | 6.27 |
| CHEMBL3759443 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL3759882 | — | Ki | = | 1169.0 | nM | 5.93 |
| CHEMBL3759447 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL1351474 | ACESULFAME POTASSIUM | Ki | = | 2410.0 | nM | 5.62 |
| CHEMBL3759567 | — | Ki | = | 2482.0 | nM | 5.61 |