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Assay Detail

CHEMBL3762573

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at delta opioid receptor (unknown origin)
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multitarget opioid ligands in pain relief: New players in an old game.
Turnaturi R, Aricò G, Ronsisvalle G, Parenti C, Pasquinucci L.
Eur J Med Chem (2016) 108 : 211 -228
PubMed 26656913 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 8.81 10.68
IC50 1 5.90 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3758292 1 10.68
CHEMBL3758712 1 9.80
CHEMBL3759292 1 9.80
CHEMBL3758257 1 9.59
CHEMBL3759383 1 9.36
CHEMBL3758259 1 9.32
CHEMBL3759238 1 9.00
CHEMBL301160 BUTORPHAN 1 8.89
CHEMBL583066 1 8.74
CHEMBL3759489 1 8.71
CHEMBL3758231 1 8.32
CHEMBL326684 1 7.88
CHEMBL3759092 1 7.54
CHEMBL285479 1 5.90
CHEMBL2181202 1 5.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3758292 Ki = 0.021 nM 10.68
CHEMBL3758712 Ki = 0.16 nM 9.80
CHEMBL3759292 Ki = 0.16 nM 9.80
CHEMBL3758257 Ki = 0.259 nM 9.59
CHEMBL3759383 Ki = 0.44 nM 9.36
CHEMBL3758259 Ki = 0.48 nM 9.32
CHEMBL3759238 Ki = 1.0 nM 9.00
CHEMBL301160 BUTORPHAN Ki = 1.3 nM 8.89
CHEMBL583066 Ki = 1.8 nM 8.74
CHEMBL3759489 Ki = 1.95 nM 8.71
CHEMBL3758231 Ki = 4.79 nM 8.32
CHEMBL326684 Ki = 13.3 nM 7.88
CHEMBL3759092 Ki = 29.0 nM 7.54
CHEMBL285479 IC50 = 1247.0 nM 5.90
CHEMBL2181202 Ki = 2100.0 nM 5.68