Assay Detail
Functional
CHEMBL3762661
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Agonist activity at human recombinant DOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.44 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405618 | ANALOG OF DYNORPHIN A | — | 1 | 7.73 |
| CHEMBL31421 | — | — | 1 | 7.57 |
| CHEMBL3759179 | — | — | 1 | 7.27 |
| CHEMBL3759167 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405618 | ANALOG OF DYNORPHIN A | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL31421 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL3759179 | — | EC50 | = | 53.7 | nM | 7.27 |
| CHEMBL3759167 | — | EC50 | = | 64.57 | nM | 7.19 |