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Assay Detail

CHEMBL3762923

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5-HT2C receptor (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL225)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives.
Landagaray E, Ettaoussi M, Duroux R, Boutin JA, Caignard DH, Delagrange P, Melnyk P, Berthelot P, Yous S.
Eur J Med Chem (2016) 109 : 360 -370
PubMed 26820449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 6.40 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3759802 1 6.85
CHEMBL10878 AGOMELATINE 4.0 1 6.20
CHEMBL3759677 1 6.14
CHEMBL3758225 1 -
CHEMBL3758717 1 -
CHEMBL3758720 1 -
CHEMBL3759816 1 -
CHEMBL3759606 1 -
CHEMBL3758679 1 -
CHEMBL3759859 1 -
CHEMBL3759160 1 -
CHEMBL3759084 1 -
CHEMBL3759661 1 -
CHEMBL3760044 1 -
CHEMBL3759080 1 -
CHEMBL3759180 1 -
CHEMBL3759372 1 -
CHEMBL3759054 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3759802 Ki = 140.0 nM 6.85
CHEMBL10878 AGOMELATINE Ki = 630.0 nM 6.20
CHEMBL3759677 Ki = 730.0 nM 6.14
CHEMBL3758225 Ki > 10000.0 nM -
CHEMBL3758717 Ki > 10000.0 nM -
CHEMBL3758720 Ki > 10000.0 nM -
CHEMBL3759816 Ki > 10000.0 nM -
CHEMBL3759606 Ki > 1000.0 nM -
CHEMBL3758679 Ki > 10000.0 nM -
CHEMBL3759859 Ki > 10000.0 nM -
CHEMBL3759160 Ki > 10000.0 nM -
CHEMBL3759084 Ki > 10000.0 nM -
CHEMBL3759661 Ki > 10000.0 nM -
CHEMBL3760044 Ki > 1000.0 nM -
CHEMBL3759080 Ki > 10000.0 nM -
CHEMBL3759180 Ki > 10000.0 nM -
CHEMBL3759372 Ki > 10000.0 nM -
CHEMBL3759054 Ki > 10000.0 nM -