Assay Detail
Binding
CHEMBL3762926
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Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | 293F |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Palmitoleoyl-protein carboxylesterase NOTUM (CHEMBL3758064) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 42 | 7.46 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3759074 | — | — | 1 | 8.22 |
| CHEMBL3760048 | — | — | 1 | 8.22 |
| CHEMBL3758280 | — | — | 1 | 8.15 |
| CHEMBL3758963 | — | — | 1 | 8.15 |
| CHEMBL3759297 | — | — | 1 | 8.15 |
| CHEMBL3758291 | — | — | 1 | 8.10 |
| CHEMBL3758275 | — | — | 1 | 8.10 |
| CHEMBL3759274 | — | — | 1 | 8.05 |
| CHEMBL3758560 | — | — | 1 | 7.92 |
| CHEMBL3759069 | — | — | 1 | 7.89 |
| CHEMBL3760062 | — | — | 1 | 7.89 |
| CHEMBL3759323 | — | — | 1 | 7.85 |
| CHEMBL3758326 | — | — | 1 | 7.80 |
| CHEMBL3758279 | — | — | 1 | 7.77 |
| CHEMBL3759908 | — | — | 1 | 7.77 |
| CHEMBL3759117 | — | — | 1 | 7.75 |
| CHEMBL3759576 | — | — | 1 | 7.72 |
| CHEMBL3760106 | — | — | 1 | 7.70 |
| CHEMBL3759044 | — | — | 1 | 7.68 |
| CHEMBL3758668 | — | — | 1 | 7.64 |
| CHEMBL3759027 | — | — | 1 | 7.57 |
| CHEMBL3758454 | — | — | 1 | 7.55 |
| CHEMBL3759406 | — | — | 1 | 7.51 |
| CHEMBL3759035 | — | — | 1 | 7.44 |
| CHEMBL3759995 | — | — | 1 | 7.42 |
| CHEMBL3758201 | — | — | 1 | 7.41 |
| CHEMBL3758520 | — | — | 1 | 7.41 |
| CHEMBL3758861 | — | — | 1 | 7.39 |
| CHEMBL3759700 | — | — | 1 | 7.34 |
| CHEMBL3760065 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3759074 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3760048 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3758963 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3759297 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3758280 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3758291 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3758275 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3759274 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3758560 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3759069 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3760062 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3759323 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3758326 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3758279 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3759908 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3759117 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3759576 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3760106 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3759044 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3758668 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3759027 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3758454 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3759406 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3759035 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3759995 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3758201 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3758520 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3758861 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3759700 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3760065 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3758239 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3758678 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3759635 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3760070 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3759129 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3758297 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3759300 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3759068 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL1421818 | — | EC50 | = | 361.0 | nM | 6.44 |
| CHEMBL3758736 | — | EC50 | = | 706.0 | nM | 6.15 |
| CHEMBL3758532 | — | EC50 | = | 1185.0 | nM | 5.93 |
| CHEMBL1499110 | — | EC50 | = | 1360.0 | nM | 5.87 |