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Assay Detail

CHEMBL3766325

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
Tan CJ, Zhao Y, Goto M, Hsieh KY, Yang XM, Morris-Natschke SL, Liu LN, Zhao BY, Lee KH.
Bioorg Med Chem Lett (2016) 26 : 1495 -1497
PubMed 26865176 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.02 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 7.75
CHEMBL3765322 1 4.66
CHEMBL3765504 1 4.35
CHEMBL3764263 1 4.17
CHEMBL3763471 1 4.17
CHEMBL3764664 1 -
CHEMBL1824581 SOPHORIDINE 1 -
CHEMBL3590540 1 -
CHEMBL3765820 1 -
CHEMBL377725 SOPHOCARPINE 1 -
CHEMBL3763416 1 -
CHEMBL382625 1 -
CHEMBL204747 1 -
CHEMBL204860 MATRINE 1 -
CHEMBL3764665 1 -
CHEMBL3763538 1 -
CHEMBL3765803 1 -
CHEMBL3765047 1 -
CHEMBL3763553 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 18.0 nM 7.75
CHEMBL3765322 IC50 = 21900.0 nM 4.66
CHEMBL3765504 IC50 = 45000.0 nM 4.35
CHEMBL3764263 IC50 = 68000.0 nM 4.17
CHEMBL3763471 IC50 = 67000.0 nM 4.17
CHEMBL3764664 IC50 > 40000.0 nM -
CHEMBL1824581 SOPHORIDINE IC50 > 80000.0 nM -
CHEMBL3590540 IC50 > 40000.0 nM -
CHEMBL3765820 IC50 > 40000.0 nM -
CHEMBL377725 SOPHOCARPINE IC50 > 40000.0 nM -
CHEMBL3763416 IC50 > 40000.0 nM -
CHEMBL382625 IC50 > 40000.0 nM -
CHEMBL204747 IC50 > 40000.0 nM -
CHEMBL204860 MATRINE IC50 > 40000.0 nM -
CHEMBL3764665 IC50 > 40000.0 nM -
CHEMBL3763538 IC50 > 40000.0 nM -
CHEMBL3765803 IC50 > 40000.0 nM -
CHEMBL3765047 IC50 > 40000.0 nM -
CHEMBL3763553 IC50 > 40000.0 nM -