Assay Detail
Functional
CHEMBL3766378
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Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by fluorescence microplate reader method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.66 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.14 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 4.51 |
| CHEMBL3763161 | — | — | 1 | 4.40 |
| CHEMBL3764339 | — | — | 1 | 4.40 |
| CHEMBL3765669 | — | — | 1 | 4.35 |
| CHEMBL3764179 | — | — | 1 | 4.18 |
| CHEMBL3764759 | — | — | 1 | - |
| CHEMBL3765132 | — | — | 1 | - |
| CHEMBL3765289 | — | — | 1 | - |
| CHEMBL3764409 | — | — | 1 | - |
| CHEMBL3763936 | — | — | 1 | - |
| CHEMBL3763763 | — | — | 1 | - |
| CHEMBL3763574 | — | — | 1 | - |
| CHEMBL3763952 | — | — | 1 | - |
| CHEMBL3764669 | — | — | 1 | - |
| CHEMBL3764946 | — | — | 1 | - |
| CHEMBL3763364 | — | — | 1 | - |
| CHEMBL3765144 | — | — | 1 | - |
| CHEMBL3765304 | — | — | 1 | - |
| CHEMBL3764692 | — | — | 1 | - |
| CHEMBL3764802 | — | — | 1 | - |
| CHEMBL3764979 | — | — | 1 | - |
| CHEMBL3763645 | — | — | 1 | - |
| CHEMBL3763765 | — | — | 1 | - |
| CHEMBL3763204 | — | — | 1 | - |
| CHEMBL3763223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL941 | IMATINIB | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3763161 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL3764339 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL3765669 | — | IC50 | = | 44270.0 | nM | 4.35 |
| CHEMBL3764179 | — | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL3764759 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3765132 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3765289 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764409 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763936 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3763763 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763574 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3763952 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764669 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764946 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763364 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3765144 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3765304 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764692 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764802 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3764979 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763645 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763765 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763204 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3763223 | — | IC50 | > | 25000.0 | nM | - |