Assay Detail
Binding
CHEMBL3766467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human alpha7 receptor expressed in mouse Neuro2a cells assessed as induction of intracellular calcium level preincubated with PNU-120596 for 20 mins followed by compound addition measured every 2 sec for 3 mins by fluorescence microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Neuro2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New quinoline derivatives as nicotinic receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.87 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764496 | — | — | 1 | 5.96 |
| CHEMBL3763220 | — | — | 1 | 5.85 |
| CHEMBL3765305 | — | — | 1 | 5.80 |
| CHEMBL3764445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764496 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3763220 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3765305 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3764445 | — | EC50 | - | — | - |