Assay Detail
Binding
CHEMBL3766503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal 6His-tagged VEGFR-2 (unknown origin) using FL-Peptide 22 as substrate after 90 mins by mobility shift assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances in the development of dual VEGFR and c-Met small molecule inhibitors as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.47 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.75 |
| CHEMBL3764045 | TAS-115 | 1.0 | 1 | 7.52 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3764045 | TAS-115 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 72.0 | nM | 7.14 |