Assay Detail
Binding
CHEMBL3766680
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Inhibition of recombinant human HDAC8 by fluorimetry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.51 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763386 | — | — | 1 | 7.27 |
| CHEMBL3764728 | — | — | 1 | 6.96 |
| CHEMBL3763388 | — | — | 1 | 6.89 |
| CHEMBL3764525 | — | — | 1 | 6.64 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.44 |
| CHEMBL3764442 | — | — | 1 | 5.70 |
| CHEMBL3765502 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763386 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3764728 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3763388 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3764525 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3764442 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3765502 | — | IC50 | = | 2200.0 | nM | 5.66 |