Assay Detail
Binding
CHEMBL3766854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of glycogen phosphorylase in Wistar rat hepatocytes assessed as decrease in glucagon stimulated glucose release after 3 hrs by glucose oxidase method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, liver form (CHEMBL3239) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.61 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765349 | — | — | 1 | 4.87 |
| CHEMBL3763876 | — | — | 1 | 4.52 |
| CHEMBL594021 | — | — | 1 | 4.44 |
| CHEMBL3763929 | — | — | 1 | - |
| CHEMBL3763976 | — | — | 1 | - |
| CHEMBL3764195 | — | — | 1 | - |
| CHEMBL3764911 | — | — | 1 | - |
| CHEMBL3764775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765349 | — | IC50 | = | 13580.0 | nM | 4.87 |
| CHEMBL3763876 | — | IC50 | = | 30070.0 | nM | 4.52 |
| CHEMBL594021 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3763929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3763976 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3764775 | — | IC50 | > | 100000.0 | nM | - |