Assay Detail
Binding
CHEMBL3766880
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Inhibition of Dengue virus 2 recombinant 6xHis-tagged NS2B/NS3 serine protease using Boc-Gly-Arg-Arg-AMC as substrate measured for 60 mins by fluorimetric analysis
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of antiviral molecules for dengue: In silico search and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 5 | 4.81 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763384 | — | — | 2 | 5.04 |
| CHEMBL3763814 | — | — | 2 | 4.76 |
| CHEMBL32926 | — | — | 2 | 4.72 |
| CHEMBL3763557 | — | — | 2 | 4.70 |
| CHEMBL3764867 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763384 | — | IC50 | = | 9090.0 | nM | 5.04 |
| CHEMBL3763814 | — | IC50 | = | 17460.0 | nM | 4.76 |
| CHEMBL32926 | — | IC50 | = | 18890.0 | nM | 4.72 |
| CHEMBL3763557 | — | IC50 | = | 19870.0 | nM | 4.70 |
| CHEMBL3763384 | — | Inhibition | - | % | - | |
| CHEMBL3763814 | — | Inhibition | - | % | - | |
| CHEMBL3763557 | — | Inhibition | - | % | - | |
| CHEMBL32926 | — | Inhibition | - | % | - | |
| CHEMBL3764867 | — | Inhibition | - | % | - | |
| CHEMBL3764867 | — | IC50 | = | 608230.0 | nM | - |